Alcohol Dehydrogenase with NAD Coenzyme from the Protein Data Base

Alcohol Dehydrogenase with NAD Coenzyme

Entry retrieved from the Protein Data Bank at RCSB.

1CDO: Oxidoreductase (Ch-Oh(D)-Nad(A)). Date: Sep 29, 1995.
Title: Alcohol Dehydrogenase (E.C.1.1.1.1) (Ee Isozyme)
Complexed With Nicotinamide Adenine Dinucleotide (Nad), And Zinc
Authors: S.Ramaswamy, M.El Ahmad, O.Danielsson, H.Jornvall, H.Eklund
Source: Organism_scientific: Gadus Callarias
Method: X-Ray Diffraction. Resolution 2.05 Ang.

The NAD coenzymes and the Zn co-factors are displayed as they occur in the X-ray structure of the holoenzyme formed with alcohol dehydrogenase. You might chose a ball & stick display to better identify the molecular constituents of NAD. Can you see the niacinamide? Can you see the adenine? Which group would be different for NADP and in what way would it be different?

Figure. The X-ray structure of alcohol dehydrogenase with NAD coenzyme and zinc cation.