IMPORTANT NOTES Experiment 3: Studying SN1 and SN2 Reactions -- CER REAC 714 Experiment 3 will be carried out in pairs. But each student provides separate prelab, recordings and post-lab. Only the execution of the labs is done in pairs. 1. Use Macroscale experiment, starts on page 6. 2. Since you are working in the hood, there is no need to connect a Y-tube to your condenser in Section 1 page 8. There are no aspirators in the labs. 3. Section 2, cool flask after refluxing in cold water bath (to speed up process). Pot residue goes in "Unwanted Materials" container. 4. Section 3, no need to transfer sample to a centrifuge tube. After removing as much of the water as possible, dry the product with CaCl2, filter through a small cotton plug into a tared container. Record the weight. 5. Omit final (optional) distillation. 6. You will characterize the product by IR analysis only. TAs will demonstrate. Water damages IR cells, so the sample has to be DRY (not cloudy) before IR analysis. 7. TAs will show how to use EPPENDORF micropipettes. There is one micropipette for every two students. Include the following Table in your lab book. This is the "table" referred to in the file "grading scheme". Bimolecular Nucleophilic Substitution gram mol amount of butanol used __________ __________ amount of 1-bromobutane produced __________ __________ product theoretical yield __________ __________ product percent yield, % __________ Unimolecular Nucleophulic Substitution Compound Time Leaving group 2-bromo-2-methylpropane __________ 2-chloro-2-methylpropane __________ Alkyl structure 2-bromo-2-methylpropane __________ 2-bromopropane __________ Solvent polarity 40% 2-propanol __________ 60% 2-propanol __________