MU Chemistry 416 FS97

NOE Literature

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Structure Determination of a Tetrasaccharide: Transient Nuclear Overhauser Effects in the Rotating Frame. Aksel A. Bothner-By, Richard L. Stephens, and Ju-mee Lee J. Am. Chem. Soc. 1984, 106, 811-813.

This article described the CAMELSPIN (cross-relaxation appropriate for minimolecule emulated by locked spins) technique which has come to be known as the ROESY technique. ROESY stands for rotating frame NOESY. The advantages of ROESY are that (a) the NOE is positive and never vanishes (no matter how large the molecule) and (b) the multispin effects are minor.

FAST NOESY Experiments - An Approach for Fast Structure Determination Matthias Koeck and Christian Griesinger Angew. Chem. Int. Ed. Engl. 1994, 33, 332-334.

NOESY and ROESY allow for the simultanesous measurement of all interproton distances in a molecule. Here a procedure is described that allows a reduction of the acquisition time of NOESY and ROESY spectra by a fcator of 5 to 10 without any loss in accuracy. The incomplete cross-relaxation between scans is taken account of via the Liouville-von-Neumann equation.

Selective Enhancement of NMR Signals for alpha-Cyclodextrin wit Laser-Polarized Xenon. Y.-Q. Song, B. M. Goodson, R. E. taylor, D. D. Laws, G. Navon, A. Pines Angew. Chem. Int. Ed. Engl. 1997, 33, 2368-2370.

The authors describe a new NMR experiment, the spin polarization induced nuclear Overhauser effect or SPINOE for short. Xe is spin polarized by laser polarization and the polarization is transferred to H spins. The Xe polarization can be positiove and negative and SPINOE difference spectra are recorded. The polarization transfer is most efficient for H-atoms that are close to the Xe (obviously) and, therefore, the method provides a probe for the sites most likely in conctact with the Xe. In this case, the Xe is inside the cavity and the largest SPINOE is seen for the H atoms pointing inside. (This article made the cover of Angewandte Chemie.)

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